Drug Metabolism Letters

Aims & Scope

Drug Metabolism Letters publishes letters, original research articles, mini-reviews, thematic issues based on mini-reviews and letters, commentaries, technical notes and drug clinical trial studies on major advances in all areas of drug metabolism and disposition.

In vitro ...read more

  • ISSN (Print): 1872-3128
  • ISSN (Online): 1874-0758
  • Volume: 14
  • Issues: 3, 2021
2.7
Drug Metabolism Letters

Volume 14, Issue 3, 2021


Short Communication open access plus
The Catalytic Activity of GSTM1 In vitro is Independent of MAPK8

Pp: 163-165

Author(s): Shannon Robin, Khalil Ben Hassine, Simona Jurkovic Mlakar, Vid Mlakar, Marc Ansari* and Chakradhara Rao S. Uppugunduri*

DOI: 10.2174/1872312814666211122164456

Published on: 17 December, 2021

Review Article
Physiological and Pathophysiological Role of Cysteine Metabolism in Human Metabolic Syndrome

Pp: 177-192

Author(s): Arunachalam Muthuraman*, Muthusamy Ramesh*, Sohrab A. Shaikh, Subramanian Aswinprakash and Dhamodharan Jagadeesh

DOI: 10.2174/1872312814666211210111820

Research Article
Analysis between Linagliptin and Azithromycin: In vitro and In vivo Interaction Study

Pp: 193-205

Author(s): Md. Didaruzzaman Sohel, Faisal Asif*, Tonmoy Kumar Mondal, Md. Helal Uddin Sumon and Md. Hassan Kawsar

DOI: 10.2174/1872312814666210910123056

Published on: 08 December, 2021

Research Article open access plus
Comparative In vitro Metabolism of Enflicoxib in Dogs, Rats, and Humans: Main Metabolites and Proposed Metabolic Pathways

Pp: 206-218

Author(s): Josep Solà, Àngel Menargues, Josep Homedes*, Marta Salichs, Maria Teresa Serafini and Gregorio Encina

DOI: 10.2174/1872312814666211209161933

Published on: 22 December, 2021

Research Article
Ameliorative Effect of Acetyl L-carnitine in Alzheimer's Disease via Downregulating of Homocysteine Levels in Hyperhomocysteinemia Induced Cognitive Deficit in Mouse Model

Pp: 219-231

Author(s): Nisha Verma, Jeetendra Kumar Gupta, Krishna Kumar Varshney and Rajnish Srivastava*

DOI: 10.2174/1872312814666211209102136

Published on: 21 December, 2021

Acknowledgement
Acknowledgment to Reviewers

Pp: 233-233

DOI: 10.2174/187231281403211227121256

Published on: 27 December, 2021

Corrigendum
Corrigendum: Inhibitory Effect of Codeine on Sucrase Activity

Pp: 232-232

Author(s): Dariush Minai-Tehrani, Saeed Minoui, Marzie Sepehre, Zohre Sharif-Khodai and Tooka Aavani

DOI: 10.2174/187231281403211227125217

Published on: 27 December, 2021

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    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '2750' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
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      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/IssueController.php:900
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      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/IssueController.php:907
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      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558058 and j.to_date >= 1745558058 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2750) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558058 and j.to_date >= 1745558058 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2750) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558058 and j.to_date >= 1745558058 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 2750)
      1.31msbetabenthamscien_newUserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/IssueController.php:919
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558058 and j.to_date >= 1745558058 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 11117) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558058 and j.to_date >= 1745558058 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 11117) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558058 and j.to_date >= 1745558058 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 11117)
      1msbetabenthamscien_newUserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/IssueController.php:932
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `journal_access` where `content_type_id` in (119001, 119130, 119337, 117858, 119327, 119311, 119697, 119701) and `content_type` = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      970μsbetabenthamscien_newContentAccess.php#616
      Bindings
      • 0: 119001
      • 1: 119130
      • 2: 119337
      • 3: 117858
      • 4: 119327
      • 5: 119311
      • 6: 119697
      • 7: 119701
      • 8: a
      Backtrace
      • 13. app/Models/ContentAccess.php:616
      • 14. app/Http/Controllers/IssueController.php:945
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558058 and j.to_date >= 1745558058 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 11117) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558058 and j.to_date >= 1745558058 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 11117) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 316251330 and j.to_ip >=316251330 )) and ((j.from_date <= 1745558058 and j.to_date >= 1745558058 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 11117)
      1.63msbetabenthamscien_newUserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/IssueController.php:1022
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '119001' order by au.sequence
      570μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '119130' order by au.sequence
      470μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '119337' order by au.sequence
      490μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '117858' order by au.sequence
      480μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '119327' order by au.sequence
      490μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '119311' order by au.sequence
      430μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '119697' order by au.sequence
      340μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select CONCAT(ifnull(au.first_name,''),' ',IFNULL(CONCAT(au.initials,' '),''), au.last_name) as authors, au.* FROM author au where article_id = '119701' order by au.sequence
      400μsbetabenthamscien_newAuthor.php#137
      Backtrace
      • 11. app/Models/Author.php:137
      • 12. app/Http/Controllers/IssueController.php:1154
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 649 limit 1
      540μsbetabenthamscien_newMeta.php#59
      Bindings
      • 0: 649
      Backtrace
      • 14. app/Models/Meta.php:59
      • 15. app/Http/Controllers/IssueController.php:1181
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 72 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      46.76msbetabenthamscien_newIssue.php#295
      Backtrace
      • 11. app/Models/Issue.php:295
      • 12. app/Http/Controllers/IssueController.php:1188
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues from journal j join volume v on j.journal_id = v.journal_id join year y on v.year_id = y.id where j.journal_id = 72 and y.year = 2025 order by v.volume_name+0 desc limit 1
      550μsbetabenthamscien_newIssue.php#295
      Backtrace
      • 11. app/Models/Issue.php:295
      • 12. app/Http/Controllers/IssueController.php:1189
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 72 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      46.01msbetabenthamscien_newIssue.php#295
      Backtrace
      • 11. app/Models/Issue.php:295
      • 12. app/Http/Controllers/IssueController.php:1191
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      800μsbetabenthamscien_newArticle.php#1959
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1959
      • 14. app/Http/Controllers/IssueController.php:1197
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 72 and `b`.`banner_from_date` <= 1745558058 and `b`.`banner_to_date` >= 1745558058 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      14.31msbetabenthamscien_newBanner.php#189
      Bindings
      • 0: 1
      • 1: J
      • 2: 72
      • 3: 1745558058
      • 4: 1745558058
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:189
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='4a1672d772edbc0936d77f813359943c'
      360μsbetabenthamscien_newCart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._main_menu:13
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
        _token
        q1KecImVq32o63CQ0hJy2oFFxkRZdUP2qYlKqLWX
        _previous
        array:1 [ "url" => "https://beta.benthamscience.com/issue/11117/1" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        uc_cart_id
        4a1672d772edbc0936d77f813359943c
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /issue/11117/1
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
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