Author(s): C.H. T.P. da Silva, V.B. da Silva and C. A. Taft
Page: [256 - 260] Pages: 5
* (Excluding Mailing and Handling)
Virtual screening docking-based approach has been employed in order to select novel HIV-1 integrase (IN) potential inhibitors in large databases. Toxicity, metabolism and drug-like properties have been analyzed for the most promising compounds, using computational chemistry techniques. Results were compared and discussed with that obtained for a known HIV-1 (IN) inhibitor reported in the literature.
Keywords: Pharmacodynamic, HIV-1 Integrase Inhibitors, Virtual screening, metabolism, computational chemistry
