Author(s): Yohannes Teffera, Daniel J. Waldon, Adria E. Colletti, Brian K. Albrecht and Zhiyang Zhao
Page: [35 - 40] Pages: 6
* (Excluding Mailing and Handling)
High resolution accurate MS with an LTQ-Orbitrap identified two novel metabolites of diclofenac in rat bile and rat and human hepatocyte incubations: a benzyl-S-glutathione conjugate and 2-(2,6-dichlorophenylamino) benzoic acid. A mechanism for the bioactivation of diclofenac involving decarboxylation is proposed.
Keywords: glutathione adduct, DPABA, diclofenac decarboxylation, Bioactivation pathway, Reconstructed ion chromatogram
