Author(s): Ashutosh J. Jani, Shivprakash Rathnam and Anita A. Mehta
Page: [5 - 10] Pages: 6
* (Excluding Mailing and Handling)
CYP3A isoforms account for about 30% of total hepatic P450s. Most statins have been accepted probes for CYP3A4. The metabolic ratio of atorvastatin/ortho-hydroxyatorvastatin showed a bimodal distribution with respect to metabolism of atorvastatin. These observations showed that the frequency of occurrence of the poor metabolizer phenotype is 2.4 % in the Gujarat subjects.
Keywords: Cytochrome P450, atorvastatin, phenotype, gujarati, CYP3A4
