Drug Metabolism Letters

Author(s): Yunsheng Hsieh, Jiwen Chen, Ian Knemeyer, Lee Crossman and Walter A. Korfmacher

DOI: 10.2174/187231208783478461

Cite As
Visualization of First-Pass Drug Metabolism of Terfenadine by MALDIImaging Mass Spectrometry

Page: [1 - 4] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

The aim of this article is to focus on the implementation and the application of matrix-assisted laser desorption/ ionization-imaging mass spectrometric system (MALDI-IMS) to determine the disposition or biotransformation pathway of terfenadine and its active metabolite, fexofenadine in mouse and rat whole-body tissue sections. Whole-body MALDI-IMS data showed that the poor oral bioavailability of terfenadine was largely due to high first-pass metabolism in the intestines and the liver before the compound reached systemic circulation.

Keywords: Imaging mass spectrometry, MALDI, first-pass metabolism