Abstract

The last decade has seen a number of important advances in the use of animal models of atherosclerosis progression. Small animal models, particularly mouse knockouts and rabbit models, are finding increasing use. This review discusses those models of particular research utility, highlights their advantages and limitations, and specifically addresses methodologies and current developments, in what is a rapidly changing field.

Keywords: C57BL/6J mice, Apolipoprotein E, fibrous plaque, Atherosclerosis Imaging, Endpoint Assessment, intravascular ultrasound