Author(s): Wing Lam, Cho-Ming Loi, James Atherton, Wayne Stolle, John Easter and Abdul Mutlib
Page: [179 - 188] Pages: 10
* (Excluding Mailing and Handling)
Profiling of rat plasma using a highly sensitive LC-ARC-MS technique showed that [3H] mefenamic acid was metabolized to several products, including a sulfate conjugate and a hydroxylated analogue as major metabolites. This technique of detecting low levels of radioactivity in plasma was superior to previously used methods, such as β-RAM detectors.
Keywords: Mefenamic acid metabolism, sulfate, glucuronide, LC-ARC-MS, plasma
