Author(s): Punam Sandhu, Paul A. Andrews, Maribeth P. Baker, Kenneth A. Koeplinger, Eric D. Soli, Thomas Miller and Thomas A. Baillie
Page: [153 - 161] Pages: 9
* (Excluding Mailing and Handling)
The disposition of vorinostat, an anticancer agent, was investigated in rats and dogs. Vorinostat possessed high serum clearance, a short elimination half-life and low oral bioavailability in both species. The renal route played an important role in the elimination of drug-related material and vorinostat was eliminated primarily by metabolic biotransformation.
Keywords: Vorinostat, histone deacetylases, glucuronidation, β-oxidation, 4-anilino-4-oxobutanoic acid
