Drug Metabolism Letters

Author(s): Takahiro Kubota

DOI: 10.2174/187231207780363679

Cite As
Brief Review of Polymorphic Drug-Metabolizing Enzymes in Japanese Populations: Development of a Higher-Throughput Genotyping Method and Proposed Applications

Page: [137 - 142] Pages: 6

  • * (Excluding Mailing and Handling)

Abstract

Different functional alleles for each subtype of cytochrome P450 (CYPs), thiopurine S-methyltransferase (TPMT), glutathione S-transferase (GST) and sulfotransferase (SULT) enzymes, have been identified. In this review, the genetic polymorphisms of drug-metabolizing enzymes in the Japanese population and their effects on metabolic activity are described in detail.

Keywords: CYP2C9, CYP2C19, CYP2D6, thiopurine S-methyltransferase, glutathione S-transferase and sulfotransferase 1A1