Intracellular Delivery of Nanogel-Quantum Dot Hybrid Nanoparticles into Human Periodontal Ligament Cells

Tomoe      Fukui; Hiroaki      Kobayashi; Urara      Hasegawa; Toshiyuki      Nagasawa; Kazunari      Akiyoshi; Isao      Ishikawa

Drug Metabolism Letters

Author(s): Tomoe Fukui, Hiroaki Kobayashi, Urara Hasegawa, Toshiyuki Nagasawa, Kazunari Akiyoshi and Isao Ishikawa

DOI: 10.2174/187231207780363570

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Intracellular Delivery of Nanogel-Quantum Dot Hybrid Nanoparticles into Human Periodontal Ligament Cells

Page: [131 - 135] Pages: 5

* (Excluding Mailing and Handling)

Abstract

Nanogels of cholesterol-bearing pullulan modified with amino-groups (CHPNH2) were utilized as a career to introduce quantum dots (QDs) into periodontal ligament (PDL) cells. Nanogel-QD effectively labeled PDL cells over 3 weeks. These results indicate that CHPNH2nanogels have a potential as a research tool in the studies of intracellular delivery system.

Keywords: Periodontal ligament cell, intracellular delivery, nanogel, quantum dot, live cell imaging

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