Author(s): Ziqiang (Zack) Cheng, Christine E. Herron, Gary Bowers and Mark de Serres
Page: [109 - 120] Pages: 12
* (Excluding Mailing and Handling)
Fresh hepatocytes have been the choice for interspecies comparative drug metabolism studies. Cryopreserved hepatocytes represent a readily available alternative when combined with acceptance limits based on the metabolic turnover of 7-ethoxycoumarin. Results for the ten NCEs examined show that the metabolites formed were strongly correlated in fresh and cryopreserved hepatocytes.
Keywords: Cryopreserved hepatocytes, fresh hepatocytes, comparative metabolism, metabolite profiling, structural identification, radiochemical flow detection
