Author(s): F. Desmoulin, C. Claparols, D. Bon, G. Larrieu, R. Martino and M. Malet-Martino
Page: [101 - 107] Pages: 7
* (Excluding Mailing and Handling)
Glucuronidation of 5-DFCR, a metabolite of capecitabine, was confirmed in experimental models from rats whereas 5-DFCR glucuronide was detected neither in bile or liver from mice nor in livermicrosomes from human. Metabolic interactions at the level of the glucuronidation pathway between CAP and other drugs are unlikely in patients.
Keywords: Capecitabine, glucuronide, human, rat, mice, cytidine deaminase
