Author(s): Thomas K. H. Chang, Jie Chen and Chia-Ting Yu
Page: [13 - 16] Pages: 4
* (Excluding Mailing and Handling)
Piceatannol and its parent compound, trans-resveratrol, decreased the in vitro catalytic activity of rat CYP1A1 and CYP1A2 by mixed inhibition. trans-Resveratrol was not a mechanism-based inactivator of rat CYP1A in vitro and the administration of this compound (50 mg/kg) to rats did not affect hepatic microsomal CYP1A-mediated enzyme activity.
Keywords: CYP1A1, CYP1A2, cytochrome P450, piceatannol, trans-resveratrol
