Abstract

A series of new cinnamide dimers was synthesized (5a-6a) and evaluated for their antimicrobial and antifungal activity. All the compounds investigated have shown significant antimicrobial activity against gram-positive and gram-negative bacterial strains, as well as few fungal strains. The compounds having withdrawing group exhibited significant biological activity than their precursors. Moreover all the compounds containing electron withdrawing substituent showed good antimicrobial activity in comparison with the standards.

Keywords: Antibacterial, Antifungal, Cinnamide dimers, Piperazine, antimicrobial activity, antifungal activity, methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant epidermidis (MRSE), vancomycin, VRE, enterococci, Crixivan, N-Boc piperazine, Aspergillus