Abstract

4, 5, 6, 7-Tetrahydropravastatin and its sodium salt as the hydrogenated derivatives of pravastatin were evaluated as HMG-CoA reductase inhibitor in vitro and in vivo, and they exhibited similar antihyperlipidaemic activity to pravastatin. The results could be regarded as a particular case to the reported SARs of statins up to now.

Keywords: Crystal structure, HMG-CoA reductase, hydrogenation, pravastatin, 4, 5, 6, 7-tetrahydropravastatin, Tetrahydropravastatin, Staphylococcus aureus, SARs, HMG-CoA, CHD, Atherosclerotic, LDL-C, rhabdomoylsis, Elemental analyses