Author(s): Juan-Juan Wang, Hong-Jin Han, Guang-Zhi Zeng, Hui Xu and Ning-Hua Tan
Page: [857 - 860] Pages: 4
* (Excluding Mailing and Handling)
To search for potential anti-cancer analogs, 16 aromatic esters of 4-demethyl-4-deoxypodophyllotoxin (6a-p) were synthesized and tested their cytotoxicity on six cancer cell lines. The results indicated that all derivatives showed potent cytotoxic activity against A-549 cell line with IC50 values of 0.00009-0.037 μg/mL.
Keywords: Aromatic ester, Cytotoxicity, Deoxypodophyllotoxin, Aromatic Esters, Podophyllotoxin, antiproliferative, antitumor, carboxylalkyl, MS, 1H NMR, HRMS, Reed-Muench method
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