Abstract

A series of benzothiazole sulfonamides, thiosemicarbazones and guanidine derivatives were synthesized by different pathways and tested for the neurotoxicity studies by the Rotarod method. The minimal motor impairment, the significant results were found with compounds (7) and (3). Some of these compounds also showed anticonvulsant activity by decreasing the duration of convulsions in albino mice. Compound (3), (7) and also compound (2) were found to be increased in the onset of convulsion and other test drugs showed moderate protection and animals were recovered in these groups

Keywords: Benzothiazole sulfonamides, Carbonic Anhydrase Inhibitors, Neurotoxicity, Anticonvulsant, Epilepsy, GABA, antiepileptic drugs AEDs, rotating rod, cancer, acetazolamide (AZA), Anticonvulsant studies, antiglaucoma agents w, Rota rod method