Abstract

A number of new derivatives of monoterpenoid with a para-menthane framework 3-methyl-6-(prop-1-en-2- yl)cyclohex-3-ene-1,2-diol (-)-3 were synthesized. The antiviral activity of (-)-3 and its derivatives against the pandemic influenza virus A/California/07/09 (H1N1)v was studied in vitro. Compound (-)-3 was found to be active against this virus (selectivity index 7.5); for mononicotinate (+)-6 the selectivity index was 17. The absolute configuration of compound 6 was shown to be critical for its antiviral activity.

Keywords: Monoterpenoids, para-menthane, Nicotinate, Influenza, Pandemic, Antiviral, Chemotherapy Drugs, Influenza epidemics, Antiviral Chemotherapy, Melaleuca armillars, Methane Series, Anticonvulsant, Anti parkinsonians activiies, Isonicotinoyl Chloride Hydrochloride,, Chicken Embryos, Erythrocytes