Abstract

Quinoxaline-2, 3-dione obtained from cyclocondensation reaction of o-phenylene diamine with oxalic acid, was reacted with chlorosulphonic acid under cold condition followed by a reaction with various benzimidazoles to give 2, 3- dioxo-1, 2, 3, 4-tetrahydroquinoxaline-6-sulphonyl benzimidazoles in satisfactory yield. Their structures were confirmed using 1H NMR, IR and mass analysis. Cytotoxicity of these derivatives were evaluated by growth inhibition of HEp-2 cells in vitro. The preliminary bioassay indicated that these compounds showed moderate cytotoxicity.

Keywords: Benzimidazole, Cytotoxicity, Quinoxaline-2,3-dione, SRB method, Electrophilic substitution, Human epithelial carcinoma cell line, Hetrocycles, Organic Synthesis, Antimalarial Activities, Benzimidazole Derivatives, Pharmacological Activities, Anthelminitic Agents, Veterinarian Medicine, Human Therapeutic Areas, Oxalic acid Dihydrate, Catalyst Microwave System