Author(s): Antonio Francisco Nogueira, Elisa Carvalho Azevedo, Vitor Francisco Ferreira, Ana Jersia Araujo, Evelyne Alves dos Santos, Claudia Pessoa, Leticia Veras Costa-Lotufo, Raquel Carvalho Montenegro, Manoel Odorico de Moraes and Thatyana Rocha Alves Vasconcelos
Page: [551 - 555] Pages: 5
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A series of eleven (E)-2-benzothiazole hydrazones were synthesized and evaluated for their in vitro anticancer activities against three neoplastic cancer cells: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). Two of them, 3e and 3f, showed good cytotoxicity activity for HL-60. The results also demonstrated that compound 3f seems to be selective to HL-60 cell line, appearing as a good prototype for an antileukemia lead molecule.
Keywords: Benzothiazoles, Hydrazones, Cancer, Cytotoxicity
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