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Letters in Drug Design & Discovery

Author(s): Yuanyuan Zhang, Guangmin Chen, Yabiao Weng, Renliang Li, Yuliang Wang and Yuzhong Wang

DOI: 10.2174/157018010791306498

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Synthesis and Anticoccidial Activity of 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) Quinazolinone Derivatives

Page: [471 - 475] Pages: 5

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Abstract

A series of 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) quinazolinone derivatives (8a-k) were designed and synthesized. Their anticoccidial activities were evaluated against Eimeria tenella in vivo. The results indicated that compounds 8a, 8b and 8e exhibited anticoccidial activity against Eimeria tenella in the chickens diet with a dose of 18 mg/Kg.

Keywords: 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) quinazolinone, Derivatives, Synthesis, Anticoccidial activity, Eimeria tenella