Author(s): Eleni Pitta, Emmanuele Crespan, Athina Geronikaki, Giovanni Maga and Alberta Samuele
Page: [228 - 234] Pages: 7
* (Excluding Mailing and Handling)
Here, we show that novel 2-aryl-3-(4-adamantyl-thiazol-21,3-thiazolidin-4-one derivatives have a mixed- or fully competitive mechanism of inhibition towards HIV-1 Reverse Transcriptase with respect to the substrates of the reaction. Thus, they are interesting starting points for the development of novel NNRTIs with an uncommon mechanism of action.
Keywords: HIV-1 RT, HAART, NNRTIs, AIDS, Antiretroviral therapy, Enzyme kinetics
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