Author(s): William Brown, Thierry Hong Groblewski, Xiao Hong Yu, Rosemarie Panetta, Kemal Payza, Etienne Lessard, Stephane St-Onge, Mirek Tomaszewski, Christopher Walpole, Daniel Page, Hua Yang, Sanjay Srivastava, Claire Milburn, Helene Desfosses, Maxime Tremblay, Ziping Liu and Zhongyong Wei
Page: [208 - 213] Pages: 6
* (Excluding Mailing and Handling)
The synthesis and biological evaluation of a novel class of cannabinoid receptor agonists based on a 5- sulfonamide benzimidazole scaffold are reported. They showed a high binding affinity to both receptors with great in vivo potency. When given orally to rats, they produced a robust analgesia in different models of inflammatory and neuropathic pain.
Keywords: Benzimidazoles, Cannabinoid agonists, Antinociception
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