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Letters in Drug Design & Discovery

Author(s): Zongli Hu, Zhiping Zhao, Yan Liang, Yong Li and Guoping Chen

DOI: 10.2174/157018010790596605

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A Novel Recombinant Fusion Protein Exhibited Inhibitory Activities on Platelet Aggregation and Thrombin

Page: [182 - 187] Pages: 6

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Abstract

We designed a novel recombinant fusion protein r-NAP5-hirudin 12-residue-RGD with bi-functional inhibitory activities against platelet aggregation and thrombin. Our strategy may supply a potential multi-functional drug for the prevention and management of thrombosis.

Keywords: Thrombosis, Hirudin 12-residue, Thrombin, NAP5, Platelet aggregation, Recombinant fusion protein