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Letters in Drug Design & Discovery

Author(s): Jing Li, Wenlong Huang, Huibin Zhang and Huiping Zhou

DOI: 10.2174/157018010790596614

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Synthesis and Preliminary COX-2 Expression Inhibitory Activities of Andrographolide Derivatives

Page: [176 - 181] Pages: 6

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Abstract

The synthesis of a series of andrographolide derivatives was described and their inhibitory effects on COX-2 expression in mouse macrophages were also evaluated. Some of the tested compounds showed better inhibitory potency than andrographolide, and compound (5d) was the best one.

Keywords: Andrographolide, Derivatives, COX-2, Expression, Inhibitory activity