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Letters in Drug Design & Discovery

Author(s): Keguang Cheng, Chao Wang, Jun Liu, Juan Xie and Hongbin Sun

DOI: 10.2174/157018010790225921

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Synthesis and Evaluation of C-28 Oleanolic Acid Derivatives as Inhibitors of Glycogen Phosphorylase

Page: [116 - 121] Pages: 6

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Abstract

Synthesis and evaluation of C-28 oleanolic acid derivatives as novel inhibitors of glycogen phosphorylase have been described. The results of glycogen phosphorylase inhibition assay and structure-activity relationship (SAR) analysis are also discussed.

Keywords: Glycogen phosphorylase, Oleanolic acid, C-28 derivatives, Synthesis, Inhibition