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Letters in Drug Design & Discovery

Author(s): Ghali Brahemi, Angelika M. Burger, Andrew D. Westwell and Andrea Brancale

DOI: 10.2174/157018010789869316

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Homology Modelling of Human E1 Ubiquitin Activating Enzyme

Page: [57 - 62] Pages: 6

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Abstract

Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed.

Keywords: Ubiquitination, Human E1, Ubiquitin activating enzyme, Homology modelling