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Letters in Drug Design & Discovery

Author(s): Vitalii V. Stadnyk, Lyudmyla A. Izyumova, Yuriy A. Rzhepetskiy, Chrystyna Ya Mayor and Vasyl V. Vlizlo

DOI: 10.2174/157018010789869299

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The Antisense Oligonucleotides Decrease Expression of the Cellular Prion

Page: [23 - 26] Pages: 4

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Abstract

The subject of this work was an inhibition of cellular prion expression in vitro and in vivo by antisense oligodeoxyribonucleotides, incorporated into cationic immunoliposomes. It was shown that asODNs are able to reduce the level of PrPc expression in vitro and in vivo.

Keywords: Cellular prion, Antisense oligodesoxyribonucleotides, Immunoliposomes