Author(s): A. B. Pramod, Sivasish Sindiri, M. Ravi Shashi Nayana, Santhosh Kumar Bairy, Ravi Shekar Ananthula, Ravikumar Muttineni, Madala Srividya and M. Kishore Kumar
Page: [585 - 594] Pages: 10
* (Excluding Mailing and Handling)
Quantitative 3-D pharmacophore model was generated using 30 chemically diverse H3 receptor antagonists and tested for its productiveness using a large test set. It had 2 hydrogen bond acceptor lipids, 1 positive ionizable and 1 hydrophobic feature. Pharmacophore analysis suggested the structural features required for increased H3 receptor activity.
Keywords: Histamine, H3 receptor, Antagonist, Pharmacophore, Virtual Screening, HypoGen
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