8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine: Novel Aminobenzopentathiepine having In Vivo Anticonvulsant and Anxiolytic Activities

Tatyana   M.   Khomenko; Tatyana   G.   Tolstikova; Alexey   V.   Bolkunov; Margarita   P.   Dolgikh; Alla   V.   Pavlova; Dina   V.   Korchagina; Konstantin   P.   Volcho; Nariman   F.   Salakhutdinov

Letters in Drug Design & Discovery

Author(s): Tatyana M. Khomenko, Tatyana G. Tolstikova, Alexey V. Bolkunov, Margarita P. Dolgikh, Alla V. Pavlova, Dina V. Korchagina, Konstantin P. Volcho and Nariman F. Salakhutdinov

DOI: 10.2174/157018009789057544

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8-(Trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine: Novel Aminobenzopentathiepine having In Vivo Anticonvulsant and Anxiolytic Activities

Page: [464 - 467] Pages: 4

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Abstract

High anticonvulsive and anxiolytic activities of 8-trifluoromethyl-6-amino-benzopentathiepin 5, which can be synthesized by new simple and effective method, have been found. The transformation of the amino group in compound 5 to the amide group drastically changed the biological activity of the compounds.

Keywords: Substituted benzopentathiepins, Anticonvulsive activity, Anxiolytic activity

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