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Letters in Drug Design & Discovery

Author(s): Xiangyang Sha, Huibin Zhang, Wenlong Huang, Jinpei Zhou and Yinghong Zhou

DOI: 10.2174/157018009787847819

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Design and Synthesis of Thiazolidinedione Derivates as Selective PPARγ Modulators

Page: [224 - 227] Pages: 4

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Abstract

In this paper we reported the design, synthesis of a series of thiazolidinedione derivates. Their PPARγ activity in vitro was assessed using a reporter gene assay. In this series, it was demonstrated that compound 8f, 8g and 8h with substituted sulfonamino thiourea groups exhibited significant partial agonistic effects on PPARγ.

Keywords: Diabetes, PPAR, Synthesis, Thiazolidinedione, Sulfonamino thiourea