Generic placeholder image

Letters in Drug Design & Discovery

Author(s): Rafael V.C. Guido, Tatiane L. Balliano, Adriano D. Andricopulo and Glaucius Oliva

DOI: 10.2174/157018009787847774

DownloadDownload PDF Flyer Cite As
Kinetic and Crystallographic Studies on Glyceraldehyde-3-Phosphate Dehydrogenase from Trypanosoma cruzi in Complex with Iodoacetate

Page: [210 - 214] Pages: 5

  • * (Excluding Mailing and Handling)

Explore Articles
About Journal
For Authors
For Editors
For Reviewers

Abstract

Kinetic and crystallographic studies on the formation of the complex between iodoacetate and the enzyme glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi were conducted in order to investigate the mechanistic and structural basis underlying enzyme inactivation. The crystallographic complex reveal important structural features useful for the design of novel inhibitors.

Keywords: Parasitic infections, Trypanosoma cruzi, Inhibitors, Enzyme, Glyceraldehyde-3-phosphate dehydrogenase, X-ray crystallography