Abstract

A derivative of gossypol, 6,7,6,7-Tetrahydroxy-5,5-diisopropyl-3,3-dimethyl-[2,2] binaphthalenyl- 1,4,1,4-tetraone (Apogossypolone, ApoG2), has been synthesized from gossypol acetic acid. Its structure was identified by IR, NMR, MS spectrum and cancer cells in vitro growth inhibition experiments were performed. The results indicate that apogossypolone exerts strong in vitro growth inhibition in human prostate cancer cells, representing a promising cancer therapeutic.

Keywords: Gossypol, Apogossypolone, Synthesis, In vitro growth inhibition, Proteins