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Letters in Drug Design & Discovery

Author(s): Jia-Liang Guo, Bing-Zhou Li, Wei-Min Chen, Ping-Hua Sun and Yuqiang Wang

DOI: 10.2174/157018009787582642

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Synthesis of Substituted 1H-Pyrrol-2(5H)-ones and 2(5H)-Furanones as Inhibitors of P. aeruginosa Biofilm

Page: [107 - 113] Pages: 7

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Abstract

A series of substituted 1H-pyrrol-2(5H)-ones and three 2(5H)-furanones were designed and chemically synthesized. Their inhibitory activities against P. aeruginosa biofilm formation were investigated by using atomic force microscope (AFM) and scanning electron microscope (SEM) technologies. Brominated 1H-pyrrol-2(5H)-ones were found to significantly inhibit P. aeruginosa biofilm formation.

Keywords: Quorum sensing, Biofilm, 2(5H)-Furanones, 1H-Pyrrol-2(5H)-one, Synthesis, P. aeruginosa