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Letters in Drug Design & Discovery

Author(s): M. Teus, A. Jirgensons, M. Dambrova, R. Mezhapuke, C. G. Parsons and W. Danysz

DOI: 10.2174/157018009787158544

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Identification of GCP II Inhibitors Based on 4-Arylmethyl-3-(4- carboxyphenyl)-5-hydroxyisoxazole Scaffold

Page: [29 - 32] Pages: 4

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Abstract

Screening of a non-ionizable compound library and hit optimization studies has resulted in a series of compounds based on a 4-arylmethyl-3-(4-carboxyphenyl)-5-hydroxyisoxazole scaffold with GCP II inhibitory activity in the low micromolar range.

Keywords: Glutamate carboxypeptidase II, Glutamate, 5-hydroxyisoxazole, Lipophilicity, Synthesis