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Letters in Drug Design & Discovery

Author(s): Tiina Heikkila, Leena Peltonen, Saila Taskinen, Timo Laaksonen and Jouni Hirvonen

DOI: 10.2174/157018008785909840

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96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility

Page: [471 - 476] Pages: 6

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Abstract

Surface tension based microtensiometric method for HTS (high throughput screening) of drug solubility properties is presented. Method was tested by determining physiologically relevant parameters on the solubility of ibuprofen and indomethacin. Linear correlation was found with equilibrium solubility. According to this study, microtensiometry is a promising technique for HTS solubility testing.

Keywords: Solubility, Surface tension, Ibuprofen, Indomethacin, High throughput screening (HTS), 96-well plate