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Letters in Drug Design & Discovery

Author(s): Shahnaz Perveen, Khalid Mohammed Khan, Muhammad Arif Lodhi, Muhammad Iqbal Choudhary, Atta-ur-Rahman and Wolfgang Voelter

DOI: 10.2174/157018008785777315

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Urease and α-Chymotrypsin Inhibitory Effects of Selected Urea Derivatives

Page: [401 - 405] Pages: 5

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Abstract

A number of urea derivatives were synthesized and screened for their urease and α-chymotrypsin inhibition effects, whereby one of the compounds, N-4-nitrophenyl-N’-4’-nitrophenylurea (3), showed strong urease inhibition (IC50 = 1.25μM). We found that the same compound is also an efficient α-chymotrypsin inhibitor having an IC50 value of 3.15μM.

Keywords: Urease, α-chymotrypsin, Urea derivatives