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Letters in Drug Design & Discovery

Author(s): O. Petrov, Y. Ivanova, G. Momekov and V. Kalcheva

DOI: 10.2174/157018008785777342

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New Synthetic Chalcones: Cytotoxic Mannich Bases of 6-(4-Chlorocinnamoyl)-2(3H)-benzoxazolone

Page: [358 - 361] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

A number of Mannich bases were synthesized by a reaction between 6-(4-chlorocinnamoyl)-2(3H)-benzoxazolone, formaldehyde and secondary amines. The structures of the compounds were confirmed by elemental analysis, IR and 1H-NMR spectra. The tested compounds exhibited concentration-dependent cytotoxic effects at low micromolar concentrations with IC50 values ranging between 1.4 and 30.9 μM.

Keywords: Chalcone, 2(3H)-Benzoxazolone, Mannich base, Cytotoxicity