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Letters in Drug Design & Discovery

Author(s): Hayamitsu Adachi, Ken-Ichiro Kondo, Fukiko Kojima, Yoji Umezawa, Keiko Ishino, Hotta Kunimoto, Yoshio Nishimura and Yuzuru Akamatsu

DOI: 10.2174/157018008784912117

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Structure-Activity Relationship Study of 8-amino-2,8-dideoxy-β -KDO, a Potent CMP-KDO Synthetase Inhibitor

Page: [336 - 339] Pages: 4

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Abstract

8-Amino-2,8-dideoxy-β-KDO is a well-known inhibitor of CMP-KDO synthetase involved in the biosynthesis of lipopolysaccharide (LPS), an essential component of the outer membrane of gram-negative bacteria. Chemical modification of the hydroxyl groups of 8-amino-2,8-dideoxy- β-KDO proved that they play a crucial role in CMP-KDO synthetase inhibition.

Keywords: Gram-negative bacteria, Lipopolysaccharide (LPS), CMP-KDO synthetase inhibitor