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Letters in Drug Design & Discovery

Author(s): Ahmed Kamal, S. F. Adil, Jaki R. Tamboli, B. Siddardha and U. S.N. Murthy

DOI: 10.2174/157018008784619933

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Synthesis and Anticancer Activity of Phthalimido and Naphthalimido Substituted Dihydropyrimidone Conjugates

Page: [261 - 270] Pages: 10

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Abstract

A series of phthalimido-dihydropyrimidones (19a-l) and naphthalimido-dihydropyrimidones (23a-l) have been synthesized and some representative compounds have been evaluated for their in vitro anticancer activity. Compounds 19d, 19f and 19j are selectively active against leukemia while showing moderate activity against broad spectrum of cancer cell lines. The compounds (19a-l) and (23a-l) also have been evaluated for their antibacterial and antifungal activities.

Keywords: Biginelli reaction, One-pot synthesis, Dihydropyrimidinones, Phthalimide, Naphthalimide, Anticancer