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Letters in Drug Design & Discovery

Author(s): Chanaz Salmi, Celine Loncle, Nicolas Vidal, Michele Laget, Yves Letourneux and Jean Michel Brunel

DOI: 10.2174/157018008784084018

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New 3-Aminosteroid Derivatives as a New Family of Topical Antibacterial Agents Active against Methicillin-Resistant Staphylococcus aureus (MRSA)

Page: [169 - 172] Pages: 4

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Abstract

A series of new 3-aminosteroid derivatives was evaluated for their in vitro antimicrobial properties against human pathogens such as Gram positive bacteria. They are active against multi-resistant cocci, especially Methicillin- Resistant Staphylococcus aureus (MRSA) at average concentrations of 2.5-5.0 μg/mL and are particularly suitable for topical antibacterial use.

Keywords: Squalamine, Aminosteroid derivatives, Antibacterial agents, Resistance, MRSA