Generic placeholder image

Letters in Drug Design & Discovery

Author(s): Mei Xiao, Bi-Ke Zhu and Yu Lin Jiang

DOI: 10.2174/157018008783928445

DownloadDownload PDF Flyer Cite As
Inhibition of Human Melonoma Cell Proliferation Using Small Molecule Uracil-DNA Glycosylase Inhibitors

Page: [108 - 110] Pages: 3

  • * (Excluding Mailing and Handling)

Explore Articles
About Journal
For Authors
For Editors
For Reviewers

Abstract

Four known small molecule uracil-DNA glycosylase (UNG) inhibitors were synthesized and tested against human melanoma cells, IgR3 and MM200. They were found to be effective against cell proliferation at micromolar concentrations and to operate through a nonapoptotic mechanism. Thus, small molecules that target UNG may be useful as potential chemotherapeutic agents against human melanoma.

Keywords: Uracil-DNA glycosylase, Small molecule inhibitors, Chemo-preventive agents, Melanoma, IgR3, MM200, Anticancer drugs