Author(s): Abdel-Majid Khatib, Yannick Bontemps, Marion Lapierre, Geraldine Siegfried and Fabien Calvo
Page: [116 - 120] Pages: 5
* (Excluding Mailing and Handling)
The proprotein convertases (PCs) are serine proteases involved in various physiological processes and their overactivity or inactivity has been linked to different disorders. PCs are responsible for the proteolytic processing of various polypeptide precursors. Here, we discuss the effect of their N-terminal prosegments on various PC substrates processing and functions.
Keywords: Proprotein convertases, prosegments, inhibitors, processing, maturation, substrates
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