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Letters in Drug Design & Discovery

Author(s): Huibin Zhang, Yubin Wang, Rui Zhao, Wenlong Huang, Yunman Li and Jinpei Zhou

DOI: 10.2174/157018008783406741

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Design and Synthesis of 2-Azetidinone Cholesterol Absorption Inhibitors

Page: [39 - 42] Pages: 4

  • * (Excluding Mailing and Handling)

Abstract

In this paper we reported the design, synthesis of a series 2-azetidinones with ester or amide group in C-3 sidechain. Their cholesterol absorption inhibition activity was assessed in orally dosed, cholesterol-fed hamsters. It was demonstrated that compound 20c∼d with amid group in C-3 sidechain exhibited high cholesterol absorption inhibition activity.

Keywords: 2-Azetidinones, C-3 sidechain, Cholesterol absorption inhibition activity