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Letters in Drug Design & Discovery

Author(s): M. Urbano, S. Collina, D. Rossi, A. Carnevale Baraglia, S. Alcaro, A. Artese and O. Azzolina

DOI: 10.2174/157018007782794581

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Design and Synthesis of a (N-Alkylaminoalkyl-Substituted)Arylalkenylamide Drug Discovery Library

Page: [605 - 610] Pages: 6

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Abstract

To discover new potential sigma ligands, a library of 64 members based on a carbamidic scaffold was designed and a synthetic protocol, based on PASPS and MAOS techniques, was developed and optimized. Applying the developed protocol the library compounds were obtained in high purity, suitable for biological screening.

Keywords: Discovery library, Sigma ligands, Arylalkenylamidic scaffold, PASPS, MAOS, Molecular modeling