Author(s): Ahmed Kamal, K. Srinivasa Reddy, M. Naseer A. Khan, Rajesh V.C.R.N.C. Shetty, S. Kaleem Ahmed, K. Pranay Kumar and U. S.N. Murty
Page: [580 - 586] Pages: 7
* (Excluding Mailing and Handling)
A new method for the synthesis of quinolines has been developed by employing various novel catalysts such as Al(OTf)3, Gd(OTf)3, and TMSCl-NaI. Later, these compounds were condensed with 3-hydrazino benzothiadiazines to obtain quinoline derived [1,2,4]triazolo[1,5-b][1,2,4] benzothiadiazines. Further, these new molecules have been evaluated for their antibacterial activity and some of them have exhibited significant antibacterial activity in comparison to sulfadiazine.
Keywords: Quinolines, Benzothiadiazines, Al(OTf)3, Friedlander synthesis, TMSCl-NaI, One-pot method, Triazolobenzothiadiazine, Antibacterial activity
Download PDF Flyer