Synthesis and Biological Evaluation of a New Series of Benzothiazole-Benzothiadiazine Conjugates as Antibacterial Agents

Ahmed      Kamal; S.   Kaleem   Ahmed; K.   Srinivasa   Reddy; M.   Naseer   A. Khan; Rajesh   V.C.R.N.C.   Shetty; B.      Siddhardha; U.   S.N.   Murty; Arnab      China; V.      Nagaraja

Letters in Drug Design & Discovery

Author(s): Ahmed Kamal, S. Kaleem Ahmed, K. Srinivasa Reddy, M. Naseer A. Khan, Rajesh V.C.R.N.C. Shetty, B. Siddhardha, U. S.N. Murty, Arnab China and V. Nagaraja

DOI: 10.2174/157018007782794563

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Synthesis and Biological Evaluation of a New Series of Benzothiazole-Benzothiadiazine Conjugates as Antibacterial Agents

Page: [550 - 556] Pages: 7

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Abstract

A new series of benzothiazolo-benzothiadiazine hybrids (9a-g) has been synthesized and evaluated for their antibacterial activity against clinical isolates of Gram-positive and Gram-negative bacteria. Some of these hybrids in this series exhibited antibacterial activity comparable to ampicillin. In addition, some of the compounds showed DNA gyrase inhibitory activity at a moderate level compared to ciprofloxacin.

Keywords: Benzothiadiazines, Benzothiazoles, Antibacterial activity, DNA gyrase inhibition

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