Abstract

The thioxylation of the potent Neurokinin A antagonist MEN 10627 by Lawessons reagent showed to be potentially useful for the post-synthetic manipulation of the related family of structurally peculiar bicyclic hexapeptides, whose synthesis in combinatorial manner has been recently described.

Keywords: tachykinins, thiopeptides, thioxopeptides, lawesson reagent, atp, anti-ischaemic drugs