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Letters in Drug Design & Discovery

Author(s): Kazuyoshi Kuwano, Naoki Hagimoto, Michihiro Yoshimi, Takashige Maeyama and Yoichi Nakanishi

DOI: 10.2174/1570180043398849

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Apoptosis Signaling Pathways as Therapeutic Targets in Lung Injury

Page: [263 - 268] Pages: 6

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Abstract

Apoptosis plays a major role in homeostasis as well as proliferation and differentiation. The important role of epithelial and endothelial cell apoptosis in lung injury and repair has been demonstrated. Modulating signaling molecules of apoptosis may be effective treatment against lung injury.

Keywords: apoptosis, death receptor, mitochondria, necrosis, lung injury, fibrosis