Letters in Drug Design & Discovery

Author(s): Hiroyoshi Inoue and Sho-ichi Yamagishi

DOI: 10.2174/1570180053765138

Design of a New Phosphate Binder, Anion Exchange Resin, Based on Microcalorimeter Measurements

Page: [250 - 254] Pages: 5

  • * (Excluding Mailing and Handling)

Abstract

It has been suggested that resin wettability is advantageous for dietary phosphate binding in the gastrointestinal tract. To evaluate the effect of anion exchange resin wetting properties on in vivo phosphate binding ability, four types of ethylene glycol dimethacrylate cross-linking 4-vinylpyridinium anion exchange resins (EGDMA-4VP) were synthesized.

Keywords: phosphate binding, wetting, immersion heat, ethylene glycol dimethacrylate cross-linking 4-vinylpyridinium, sevelamer hci, gastrointestinal content